pfs ( pre filled syring ) machines
pfs ( pre filled syring ) machines
At HMEC Machines, we understand that pre-filled syringes (PFS) represent the future of parenteral drug delivery. Our HMEC Series PFS Filling & Stoppering Machines are designed to meet the rigorous demands of the biotech and pharmaceutical industries. Engineered for absolute sterility, high dosing accuracy, and zero cross-contamination, our machines ensure your delicate biologics, vaccines, and complex suspensions are handled with the utmost care.
Whether you require a compact R&D unit or a high-speed commercial production line, HMEC delivers cGMP-compliant solutions that integrate seamlessly into your cleanroom environment (Iso Class 5 / Grade A).
Types of HMEC PFS Machines
We offer a versatile range of Pre-Filled Syringe machinery to suit different production scales:
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HMEC-PFS-AUTO (High-Speed Automatic Line):
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Fully automated robotic nest handling, filling, and stoppering.
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Designed for high-volume commercial batches.
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Integrates with O-RABS (Open Restricted Access Barrier System) or Isolators.
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HMEC-PFS-SEMI (Semi-Automatic / Compact):
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Ideal for small batches, pilot plants, and clinical trials.
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Manual nest loading with automated filling and stoppering cycles.
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Compact footprint for limited cleanroom space.
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HMEC-PFS-LAB (R&D Unit):
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Tabletop or mobile unit for formulation development and stability batch filling.
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Precision low-volume filling capabilities.
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Sailent Feature
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Precision Dosing Technology: Utilizes high-accuracy Servo-Driven Valveless Ceramic Pumps or Peristaltic Pumps to achieve filling accuracy of ±0.5% to ±1%, preventing product loss of expensive APIs.
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Vacuum Stoppering System: Advanced vacuum-assisted stoppering ensures bubble-free stopper insertion, maintaining container integrity and sterility.
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No-Container, No-Fill System: Intelligent sensors detect the presence of syringes; if a slot is empty, the machine skips the fill cycle to prevent wastage and spillage.
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Aseptic Design (cGMP Compliant): Constructed with SS316L contact parts and SS304 non-contact parts. The crevice-free design allows for effective CIP/SIP (Clean-In-Place / Sterilize-In-Place).
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Recipe Management: PLC-based HMI (Human Machine Interface) stores unmatched recipes for quick changeovers between different syringe sizes (0.5ml to 10ml) without tools.
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Integrated Laminar Air Flow (LAF): Optional HEPA filter units provide a sterile air curtain over the filling zone, ensuring Class 100 protection.
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IPC (In-Process Control): Optional integrated check-weighing systems with auto-rejection for over/under-filled syringes.
Technical Specification
echnical Specifications
| Specification | HMEC-PFS-AUTO (Production) | HMEC-PFS-SEMI (Pilot/Lab) |
| Output Speed | 2,000 to 12,000 Syringes/Hour | 500 to 1,500 Syringes/Hour |
| Filling Range | 0.5 ml to 20 ml | 0.2 ml to 10 ml |
| Dosing Accuracy | ± 0.5% to 1% (volume dependent) | ± 1% |
| Syringe Compatibility | Nested Syringes (Hypak, SCF, etc.) | Nested / Individual Trays |
| Filling Pump Type | Servo Ceramic / Peristaltic | Peristaltic / Piston |
| Power Supply | 415V, 3 Phase, 50Hz | 220V, 1 Phase, 50Hz |
| Material of Construction | Contact: SS316L | Frame: SS304 | Contact: SS316L | Frame: SS304 |
| Air Consumption | 15–20 CFM @ 6 Bar | 5–8 CFM @ 6 Bar |
| Dimensions (Approx.) | 2500mm (L) x 1200mm (W) x 2100mm (H) | 1500mm (L) x 900mm (W) x 1600mm (H) |
